New Study Challenges Antidepressant Withdrawal Severity Claims

Thu Jul 17 2025 08:28:07 GMT+0300 (Eastern European Summer Time)
New Study Challenges Antidepressant Withdrawal Severity Claims

A recent investigation argues that the severity of withdrawal symptoms from antidepressants has been exaggerated, sparking new discussions on long-term medication use.


New research published in JAMA Psychiatry suggests that while some patients experience withdrawal symptoms after stopping antidepressants, these symptoms are often mild and not clinically significant.

Article text:
The ongoing conversation around antidepressant medications has been reignited by a new study questioning the purported severity of withdrawal symptoms experienced by patients. This dialogue comes in the backdrop of rising concerns over long-term medication use, which affects approximately one in nine adults in the U.S., according to the Centers for Disease Control and Prevention.

In 2019, a British study alarmingly reported that over half of patients could face withdrawal symptoms upon discontinuation of antidepressants, with nearly half of those experiencing severe effects. This triggered significant changes in psychiatric training and prescribing practices and bolstered a movement aimed at reducing psychotropic drug prescriptions. Recently, the conversation gained additional momentum with the endorsement from political figures like Robert F. Kennedy Jr.

However, a new paper published in the journal JAMA Psychiatry contests these earlier findings. Researchers discovered that, although some patients reported issues such as dizziness and nausea just a week after stopping their medications, the intensity of these symptoms generally remained “below the threshold for clinically significant” withdrawal. Dr. Sameer Jauhar, a co-author and psychiatry professor at Imperial College London, emphasized that the earlier messaging suggesting widespread severe withdrawal symptoms lacked scientific backing.

Dr. Jauhar's study indicates a need for a balanced perspective, providing reassurance to patients and healthcare providers alike, and challenging the narrative that has shaped recent public discourse on antidepressant use.

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